ea0022p22 | Adrenal | ECE2010
van der Pas Rob
, Hofland Leo
, Waaijers Marlijn
, de Jong Frank
, Uitterlinden Piet
, de Herder Wouter
, van Koetsveld Peter
, Feelders Richard
Introduction: Ketoconazole is an antifungal agent that, in a high dose, suppresses adrenocortical steroidogenesis by inhibition of cytochrome P-450 dependent enzymes. Currently, ketoconazole is used to decrease cortisol production in patients with Cushings syndrome. However, ketoconazole often causes gastrointestinal side effects and hepatotoxicity. Fluconazole may also inhibit steroidogenesis and has the advantage over ketoconazole that it has less side effects. Therefo...